Hello! Shamrat here; a first-year graduate student of Medical Biophysics in the Physics and Astronomy Department of Clemson University here in beautiful Clemson, South Carolina, United States. I received my Bachelor of Science degree in Biochemistry and Molecular Biology from BSMRSTU in Gopalganj, Bangladesh.
During my academic activities in Bangladesh, I worked on molecular modelling and molecular dynamics simulation study of proteins associated with EAE: a mouse model of Multiple Sclerosis under the supervision of Mahbub Hasan, PhD. In summer 2020, I also worked on DEGs analysis from ovarian cancer datasets as a research intern at the Cancer Biology Lab, Dept. of Biotechnology, IIT Madras, India with a GRIESHMA fellowship under the supervision of Professor Karuanagaran D. I secured a joint 2nd runner up position at the BAUET Tech Fair 2K18 at BAUET, Natore, Bangladesh for the outstanding presentation on DFT and Molecular Docking study on Delafloxacin against ABSSI.
Apart from research, I love to sketch, do check my graphite on papers here, whilst great fan of classical detective stories - Sherlock Holmes, Feluda and many more. In my off-research time, I love to teach biology to the kids at my village where I show them the fun experiments of DIY DNA extraction, glowing plants and perspective biochemistry in our daily lives.
Education
Graduate Student (Medical Biophysics). (2022 - Present)
Clemson University, SC 29634, United States.
Ongoing.
Bachelor of Science (Biochemistry and Molecular Biology). (2019)
Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Bangladesh.
Experience
Research Intern - Cancer Biology Laboratory. (Mar 2020-Sep 2020)
Indian Institute of Technology Madras, Chennai, India.
Project: Microarray data analysis using GEO2R to identify differentially expressed genes in ovarian cancer after NSC319726 treatment and pathway analysis.
Trainee - Analytical Chemistry & Environmental Science Department. (Dec 07-27, 2020)
Training Institute for Chemical Industries, Narsingdi 1611, Bangladesh.
Training: Chemical analysis and quality control.
Skills
- Biophysics: Molecular Dynamics simulation, Peptide Modeling, Molecular Docking, Microarray and NGS data analysis; elementary, Force-Fields: OPLS-aa.
- Applications: GROMACS, VMD, SWISS-MODEL, MODELLER, PyRx, Discovery Studio, PyMol, UCSF-Chimera, Gaussian9 (DFT study; elementary), Bioconda, sra-tools, FastQC, gnuPlot.
- Molecular: Plasmid/DNA/RNA/Protein extraction, Cell culture, Differential/Special Stain, rt-qPCR
- Analytical: Spectroscopic techniques, HPLC, GC-MS, ICP-OES, FTIR and EDXRF; Elementary.
- Computing: Programming: Biopython, R; MS Office: Word, Excel, PowerPoint, LibreOffice; Scientific Drawing: Inkscape, GIMP; Typing: 50 WPM in English; 35 WPM in Bengali.
- OS: Windows, Linux (Ubuntu 20.04 Distro).
- Misc.: Teaching, training, consultation in molecular modeling and simulation.
Grants and Awards
- 2020 : GRIESHMA Fellowship at IIT Madras, Chennai, India.
- 2018 : 2nd Runner up: poster presentation at BAUET Tech Fair 2K18, BAUET, Natore, Bangladesh.
Publications
- Paul, S.K. et al. (2022) Molecular modeling, molecular dynamics simulation, and essential dynamics analysis of grancalcin: An upregulated biomarker in experimental autoimmune encephalomyelitis mice. Heliyon, e11232.
- Hasan, M. et al. (2022). Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis.. Molecules 2022, 27(5), 1481.
- Ahmed, K.A., et al. (2021). Potential Role of CCN Proteins on Breast Cancer: Therapeutic Advances and Perspectives. Current Oncology, 28(6), 4972–4985.
- Seo, S.-H., Paul, S.K. et al. (2021). An insight into pathophysiological features and therapeutic advances on ependymoma. Cancers, 13(13), 3221.
- Paul, S. K., et al. (2020). In Silico Design and Homology Modeling of Helicase C-Terminal Domain of Nonstructural Protein NS3 of West Nile Virus (Strain NY-99). Springer Nature, pp: 723–732.
- Paul, S. K., et al. (2019). Structure prediction and functional characterization of Uncharacterized Protein Rv1708 of Mycobacterium tuberculosis (Strain ATCC 25618/H37Rv). CRC press. pp: 179–184.
Recent Updates
- Apr 22, 2022 - Bioexcel featured @ScienceServers; My tweet on simulation included.
- Feb 22, 2022 - IPF review has been published in Molecules [IF: 4.412].
- Feb 18, 2022 - IPF review has been accepted in Molecules [IF: 4.412].
- Jan 14, 2022 - Advanced workshop on GROMACS by CSC.fi; participant.
- Dec 30, 2021 - Awarded NST fellowship by MOST, Bangladesh.
- Dec 03, 2021 - Recieved MS thesis internship offer ICSR, IIT Palakkad, India.
- Nov 26, 2021 - Collaborative research on CCN published in Current oncology.
- Jun 28, 2021 - Ependymoma article is now online in Cancers.
Reach me –> shamratpaul.bmb@gmail.com